原创力文档ubiquitin-dependent control of class ii mhc localization is dispensable for antigen presentation and antibody productionubiquitin-dependent控制二类mhc抗原表示和抗体生产本地化是可有可无的.pdfVIP
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ubiquitin-dependent control of class ii mhc localization is dispensable for antigen presentation and antibody productionubiquitin-dependent控制二类mhc抗原表示和抗体生产本地化是可有可无的
Ubiquitin-Dependent Control of Class II MHC
Localization Is Dispensable for Antigen Presentation and
Antibody Production
¤
Annette M. McGehee , Karin Strijbis, Eduardo Guillen, Thomas Eng, Oktay Kirak, Hidde L. Ploegh*
Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, United States of America
Abstract
Controlled localization of class II MHC molecules is essential for proper class II MHC-restricted antigen presentation and the
subsequent initiation of an adaptive immune response. Ubiquitination of class II MHC molecules on cytosolic lysine (K225) of
the b-chain has been shown to affect localization of the complex. We generated mice in which the endogenous b-chain
locus is replaced with a GFP tagged mutant version that lacks the cytosolic lysine residue (I-A-b-K225R-EGFP). These mice
have elevated levels of class II MHC as compared to I-A-b-EGFP mice, and immature bone marrow-derived dendritic cells
show redistribution of class II MHC to the cell surface. Nonetheless, in these same cells efficiency of antigen presentation is
unaffected in I-A-b-K225R-EGFP mice, as assayed for presentation of ovalbumin to appropriately specific T cells. The I-A-b-
K225R-EGFP animals have normal CD4 T cell populations and are capable of generating antigen-specific antibody in
response to model antigens and viral infection. We therefore conclude that in our experimental system modulation of
trafficking by ubiquitination of residue K225 of the b-chain is not essential for the function of class II MHC products in
antigen presentation or antibody production.
Citation: McGehee AM, Strijbis K, Guillen E, Eng T, Kirak O, et al. (2011) Ubiquitin-Dependent Control of Class II MHC Localization Is Dispensable for Antigen
Presentation and Antibody Production. PLoS ONE 6(4): e18817. doi:10.1371/journal.pone.
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