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vaccines against a major cause of abortion in cattle, neospora caninum infection疫苗在牛流产的主要原因,neospora caninum感染.pdf

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vaccines against a major cause of abortion in cattle, neospora caninum infection疫苗在牛流产的主要原因,neospora caninum感染

Animals 2011, 1, 306-325; doi:10.3390/ani1030306 OPEN ACCESS animals ISSN 2076-2615 /journal/animals Review Vaccines against a Major Cause of Abortion in Cattle, Neospora caninum Infection Thierry Monney, Karim Debache and Andrew Hemphill * Institute of Parasitology, Vetsuisse Faculty, University of Berne, Länggass-Strasse 122, CH-3012 Berne, Switzerland; E-Mails: thierry.monney@vetsuisse.unibe.ch (T.M.); kardebache@yahoo.fr (K.D.) * Author to whom correspondence should be addressed; E-Mail: andrew.hemphill@vetsuisse.unibe.ch; Tel.: +41-31-631-2384; Fax: +41-31-631-2477. Received: 28 July 2011; in revised form: 30 August 2011 / Accepted: 6 September 2011 / Published: 8 September 2011 Simple Summary: We review the efforts to develop a vaccine against neosporosis, caused by the apicomplexan parasite Neospora caninum . Vertical transmission is the main mode of infection, and can lead to stillbirth, abortion, or birth of weak calves. We provide information on the biology of Neospora caninum and on the disease caused by this parasite, and summarize the current understanding on how the host deals with infection. We review studies on live- and subunit-vaccines, and demonstrate advantages and setbacks in the use of small laboratory animal models in investigations on a disease with high relevance in cattle. Abstract: Neosporosis, caused by the apicomplexan parasite Neospora caninum, represents one of