wortmannin reduces insulin signaling and death in seizure-prone pcmt1？？ mice渥曼青霉素减少胰岛素信号和死亡seizure-prone pcmt1 老鼠.pdfVIP

Wortmannin Reduces Insulin Signaling and Death in Seizure-Prone Pcmt1 2/ 2 Mice Kennen B. MacKay, Jonathan D. Lowenson, Steven G. Clarke* Department of Chemistry and Biochemistry and the Molecular Biology Institute, University of California Los Angeles, Los Angeles, California, United States of America Abstract L-isoaspartyl (D-aspartyl) O-methyltransferase deficient mice (Pcmt12/ 2) accumulate isomerized aspartyl residues in intracellular proteins until their death due to seizures at approximately 45 days. Previous studies have shown t