原创力文档combinatorial action of mirnas regulates transcriptional and post-transcriptional gene silencing following in vivo pns injury组合动作的microrna调节转录和转录后基因沉默后体内pn受伤.pdfVIP
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combinatorial action of mirnas regulates transcriptional and post-transcriptional gene silencing following in vivo pns injury组合动作的microrna调节转录和转录后基因沉默后体内pn受伤
Combinatorial Action of miRNAs Regulates
Transcriptional and Post-Transcriptional Gene
Silencing following in vivo PNS Injury
Tadepalli Adilakshmi, Ida Sudol, Nikos Tapinos*
Molecular Neuroscience Laboratory, Weis Center for Research, Geisinger Clinic, Danville, Pennsylvania, United States of America
Abstract
Injury response in the peripheral nervous system (PNS) is characterized by rapid alterations in the genetic program of Schwann
cells. However, the epigenetic mechanisms modulating these changes remain elusive. Here we show that sciatic nerve injury in
mice in
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