continuous production of prions after infectious particles are eliminated implications for alzheimer’s disease连续生产的朊病毒感染性粒子后消除对阿尔茨海默氏症的影响.pdfVIP

Continuous Production of Prions after Infectious Particles Are Eliminated: Implications for Alzheimer’s Disease Kohtaro Miyazawa, Terry Kipkorir, Sarah Tittman, Laura Manuelidis* Section of Neuropathology, Department of Surgery, Yale University Medical School, New Haven, Connecticut, United States of America Abstract Rat septal cells, induced to enter a terminal differentiation-like state by temperature shift, produce prion protein (PrP) levels 7x higher than their proliferative counterparts. Host PrP accumulates on the plasma membrane,