ctr2 links copper homeostasis to polysaccharide capsule formation and phagocytosis inhibition in the human fungal pathogen cryptococcus neoformansctr2链接铜稳态多糖胶囊形成和吞噬作用抑制人类真菌病原体新型隐球菌.pdfVIP

Ctr2 Links Copper Homeostasis to Polysaccharide Capsule Formation and Phagocytosis Inhibition in the Human Fungal Pathogen Cryptococcus neoformans Cheryl D. Chun, Hiten D. Madhani* Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, California, United States of America Abstract Cryptococcus neoformans is a human opportunistic fungal pathogen responsible for ,1/3 of HIV/AIDS deaths worldwide. This budding yeast expresses a polysaccharide capsule necessary for virulence. Capsule production inhibits phagocytosis by macroph