cultured alveolar epithelial cells from septic rats mimic in vivo septic lung培养从脓毒性大鼠肺泡上皮细胞模拟体内感染性肺.pdfVIP

Cultured Alveolar Epithelial Cells From Septic Rats Mimic In Vivo Septic Lung Taylor S. Cohen, Gladys Gray Lawrence, Susan S. Margulies* Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America Abstract Sepsis results in the formation of pulmonary edema by increasing in epithelial permeability. Therefore we hypothesized that alveolar epithelial cells isolated from septic animals develop tight junctions with different protein composition and reduced barrier function relative to alveolar epithelial cells