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deleted in malignant brain tumors-1 protein (dmbt1) a pattern recognition receptor with multiple binding sites恶性大脑中删除tumors-1蛋白(dmbt1)模式识别受体与多个结合位点
Int. J. Mol. Sci. 2010, 11, 5212-5233; doi:10.3390/ijms11 12521
OPEN ACCESS
International Journal of
Molecular Sciences
ISSN 1422-0067
/journal/ijms
Review
Deleted in Malignant Brain Tumors-1 Protein (DMBT1):
A Pattern Recognition Receptor with Multiple Binding Sites
Antoon J. M. Ligtenberg 1,*, Niclas G. Karlsson 2 and Enno C. I. Veerman 1
1 Periodontology and Oral Biochemistry, Academic Centre for Dentistry Amsterdam, G. Mahlerlaan
3004, 1081LA, Amsterdam, The Netherlands; E-Mail: e.veerman@acta.nl
2 Medical Biochemistry, University of Gothenburg, Gothenburg, Sweden Box 440, 40530
Gothenburg, Sweden; E-Mail: niclas.karlsson@medkem.gu.se
* Author to whom correspondence should be addressed; E-Mail: a.ligtenberg@acta.nl;
Tel.: +31-(0)-20-5980-896.
Received: 11 November 2010; in revised form: 9 December 2010 / Accepted: 9 December 2010 /
Published: 17 December 2010
Abstract: Deleted in Malignant Brain Tumors-1 protein (DMBT1), salivary agglutinin
(DMBT1SAG), and lung glycoprotein-340 (DMBT1GP340) are three names for glycoproteins
encoded by the same DMBT1 gene. All these proteins belong to the scavenger receptor
cysteine-rich (SRCR) superfamily of proteins : a superfamily of secreted or
membrane-bound proteins with SRCR domains that are highly conserved down to sponges,
the most ancient metazoa. In addition to SRCR domains, all DMBT1s contain two CUB
domains and one zona pellucida domain. The SRCR doma
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