原创力文档dengue virus tropism in humanized mice recapitulates human dengue fever登革病毒取向在人源化小鼠概括人类登革热.pdfVIP
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dengue virus tropism in humanized mice recapitulates human dengue fever登革病毒取向在人源化小鼠概括人类登革热
Dengue Virus Tropism in Humanized Mice Recapitulates
Human Dengue Fever
Javier Mota, Rebeca Rico-Hesse*
Department of Virology and Immunology, Southwest Foundation for Biomedical Research, San Antonio, Texas, United States of America
Abstract
Animal models of dengue virus disease have been very difficult to develop because of the virus’ specificity for infection and
replication in certain human cells. We developed a model of dengue fever in immunodeficient mice transplanted with
human stem cells from umbilical cord blood. These mice show measurable s
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