depolarization-evoked secretion requires two vicinal transmembrane cysteines of syntaxin 1adepolarization-evoked分泌需要两个附近的1突触融合蛋白的跨膜半胱氨酸.pdfVIP

Depolarization-Evoked Secretion Requires Two Vicinal Transmembrane Cysteines of Syntaxin 1A Roy Cohen, Merav Marom, Daphne Atlas* Department of Biological Chemistry, The Alexander Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem, Israel Background. The interactions of the voltage-gated Ca2+ channel (VGCC) with syntaxin 1A (Sx 1A), Synaptosome-associated protein of 25 kD (SNAP-25), and synaptotagmin, couple electrical excitation to evoked secretion. Two vicinal Cys residues, Cys 271 and Cys 272 in the Sx 1A transmembrane domain, are h