destabilizing domains mediate reversible transgene expression in the brain在大脑中不稳定域调解可逆的转基因表达.pdfVIP

Destabilizing Domains Mediate Reversible Transgene Expression in the Brain Khalid Tai, Luis Quintino, Christina Isaksson, Fredrik Gussing, Cecilia Lundberg* CNS Gene Therapy Unit, Wallenberg Neuroscience Center, Department of Experimental Medical Science, Lund University, Lund, Sweden Abstract Regulating transgene expression in vivo by delivering oral drugs has been a long-time goal for the gene therapy field. A novel gene regulating system based on targeted proteasomal degradation has been recently developed. The system is based on a destabilizing do