detecting remote sequence homology in disordered proteins discovery of conserved motifs in the n-termini of mononegavirales phosphoproteins检测远程无序的序列同源性蛋白的发现守恒的图案的n-termini mononegavirales磷蛋白质.pdfVIP

Detecting Remote Sequence Homology in Disordered Proteins: Discovery of Conserved Motifs in the N-Termini of Mononegavirales phosphoproteins David Karlin*, Robert Belshaw Department of Zoology, University of Oxford, Oxford, United Kingdom Abstract Paramyxovirinae are a large group of viruses that includes measles virus and parainfluenza viruses. The viral Phosphoprotein (P) plays a central role in viral replication. It is composed of a highly variable, disordered N-terminus and a conserved C- terminus. A second viral protein alternatively expressed, the V protein,