原创力文档determination of the membrane topology of the small ef-hand ca2+-sensing proteins cabp7 and cabp8测定膜的拓扑的小类ef - hand ca2 +敏感技术蛋白质cabp7 cabp8.pdfVIP
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determinationofthemembranetopologyofthesmallef-handca2-sensingproteinscabp7andcabp8测定膜的拓扑的小类ef-handca2敏感技术蛋白质cabp7cabp8
Determination of the Membrane Topology of the Small
EF-Hand Ca2+-Sensing Proteins CaBP7 and CaBP8
Hannah V. McCue, Robert D. Burgoyne, Lee P. Haynes*
Department of Cellular and Molecular Physiology, University of Liverpool, Liverpool, United Kingdom
Abstract
The CaBPs represent a subfamily of small EF-hand containing calcium (Ca2+)-sensing proteins related to calmodulin that
regulate key ion channels in the mammalian nervous system. In a recent bioinformatic analyses we determined that CaBP7
and CaBP8 form an evolutionarily distinct branch within the CaBPs
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