原创力文档diagnosis of parkinsons disease based on disease-specific autoantibody profiles in human sera帕金森病的诊断基于特定疾病在人类血清自身抗体的概要文件.pdfVIP
- 1、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
- 2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击 这里二次下载。
- 3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
- 4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
- 5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
- 6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
- 7、VIP文档为合作方或网友上传，每下载1次， 网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档
查看更多
diagnosis of parkinsons disease based on disease-specific autoantibody profiles in human sera帕金森病的诊断基于特定疾病在人类血清自身抗体的概要文件
Diagnosis of Parkinson’s Disease Based on Disease-
Specific Autoantibody Profiles in Human Sera
Min Han1,2., Eric Nagele3., Cassandra DeMarshall1,2, Nimish Acharya1,2, Robert Nagele2,3*
1 University of Medicine and Dentistry of New Jersey-Graduate School of Biomedical Sciences at the School of Osteopathic Medicine, Stratford, New Jersey, United States
of America, 2 New Jersey Institute for Successful Aging, University of Medicine and Dentistry of New Jersey, Stratford, New Jersey, United States of America, 3 Durin
Technologies, Inc. New Brunswick, New Jersey, United States of America
Abstract
Parkinson’s disease (PD), hallmarked by a variety of motor disorders and neurological decline, is the second most common
neurodegenerative disease worldwide. Currently, no diagnostic test exists to identify sufferers, and physicians must rely on a
combination of subjective physical and neurological assessments to make a diagnosis. The discovery of definitive blood-
borne biomarkers would be a major step towards early and reliable diagnosis. Despite attention devoted to this search, such
biomarkers have remained elusive. In the present study, we used human protein microarrays to reveal serum autoantibodies
that are differentially expressed among PD and control subjects. The diagnostic significance of each of these autoantibodies
was evaluated, resulting in the selection of 10 autoantibody biomarkers that can effectively differentiate PD sera from
control sera with a sensitivity of 93.1% and specificity of 100%. PD sera were also distinguishable from sera obtained from
Alzheimer’s disease, breast cancer, and multiple sclerosis patients with accuracies of 86.0%, 96.6%, and 100%, respectively.
Results demonstrate that serum autoantibodies can be used as highly specific and accurate biomarkers for PD diagnosis
throughout the course of the disease.
Citation: Han M, Nagele
您可能关注的文档
- degradation of internalized αvβ5 integrin is controlled by upar bound upa effect on β1 integrin activity and α-sma stress fiber assembly退化内化αvβ5整合素是由upar绑定upa影响β1整合素活动和α-sma应力纤维组装.pdf
- degradation of metalaxyl and mefenoxam and effects on the microbiological properties of tropical and temperate soils甲霜灵和mefenoxam退化对热带和温带土壤的微生物特性的影响.pdf
- degradation of microcystin-lr and rr by a stenotrophomonas sp. strain ems isolated from lake taihu, china美国退化和rr stenotrophomonas sp。应变ems隔绝太湖湖,中国.pdf
- degradation of glyphosate in soil photocatalyzed by fe3o4sio2tio2 under solar light草甘膦在土壤退化photocatalyzed由fe3o4sio2tio2太阳能灯.pdf
- degradation of phosphorylated p53 by viral protein-ecs e3 ligase complex磷酸化p53的病毒protein-ecs e3连接酶降解复杂.pdf
- degradation of rural and urban great tit song testing transmission efficiency退化的农村和城市大山雀歌测试传输效率.pdf
- degradation of psbo by the deg protease hhoa is thioredoxin dependent度蛋白酶hhoa psbo退化的硫氧还蛋白相关的.pdf
- degradation of the disease-associated prion protein by a serine protease from lichens退化疾病有关的朊蛋白的地衣的丝氨酸蛋白酶.pdf
- dehydrocostuslactone suppresses angiogenesis in vitro and in vivo through inhibition of aktgsk-3β and mtor signaling pathwaysdehydrocostuslactone体外和体内通过抑制血管生成抑制aktgsk-3βmtor信号通路.pdf
- deinococcus geothermalis the pool of extreme radiation resistance genes shrinks耐放射geothermalis极端的辐射抗性基因的范围也在缩小.pdf
- development of the bi-partite gal4-uas system in the african malaria mosquito, anopheles gambiae发展bi-partite gal4-uas系统在非洲疟疾的蚊子,冈比亚疟蚊.pdf
- diagnostic management of pancreatic cancer诊断胰腺癌的管理.pdf
- dextran and polymer polyethylene glycol (peg) coating reduce both 5 and 30 nm iron oxide nanoparticle cytotoxicity in 2d and 3d cell culture右旋糖酐和聚合物聚乙二醇(peg)涂层减少5和30纳米氧化铁纳米颗粒在2 d和3 d细胞培养细胞毒性.pdf
- diagnostic accuracy of adenosine deaminase and lymphocyte proportion in pleural fluid for tuberculous pleurisy in different prevalence scenarios诊断的准确性腺苷脱氨酶和淋巴细胞比例为结核性胸膜炎胸膜液在不同的流行情况.pdf
- diagnosis of partial body radiation exposure in mice using peripheral blood gene expression profiles诊断部分身体的辐射暴露对小鼠外周血基因表达谱.pdf
- diagnostic value of lumbar facet joint injection a prospective triple cross-over study诊断价值的腰椎方面联合注入一个前瞻性三交叉研究.pdf
- diagnostic significance of serum hmgb1 in colorectal carcinomas大肠癌癌血清hmgb1的诊断意义.pdf
- diagnostic performance of 1→3-β-d-glucan in neonatal and pediatric patients with candidemia诊断性能1→3-β-d-glucan与candidemia新生儿和儿科患者.pdf
- diamond-structured photonic crystals with graded air spheres radiidiamond-structured光子晶体与空气分级球体半径.pdf
- diaphragm muscle weakness in an experimental porcine intensive care unit model隔膜肌无力在模型实验猪重症监护室.pdf
文档评论（0）