differential regulation of transcription factors by location-specific egf receptor signaling via a spatio-temporal interplay of erk activation微分调节转录因子的具体地点的表皮生长因子受体信号通过erk活化的时空相互作用.pdfVIP

Differential Regulation of Transcription Factors by Location-Specific EGF Receptor Signaling via a Spatio- Temporal Interplay of ERK Activation Peng Wu, Ping Wee, Jennifer Jiang, Xinmei Chen, Zhixiang Wang* The Department of Medical Genetics and Signal Transduction Research Group, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada Abstract It is well established that EGFR signals from both the plasma membrane (PM) and endosome (EN). However, very little is known about whether and how the EGFR signals at the PM and EN to differentially reg