dioxin (tcdd) induces epigenetic transgenerational inheritance of adult onset disease and sperm epimutations二恶英(tcdd)诱导表观遗传继代遗传和精子表突变成人发病的疾病.pdfVIP

Dioxin (TCDD) Induces Epigenetic Transgenerational Inheritance of Adult Onset Disease and Sperm Epimutations Mohan Manikkam, Rebecca Tracey, Carlos Guerrero-Bosagna, Michael K. Skinner* Center for Reproductive Biology, School of Biological Sciences, Washington State University, Pullman, Washington, United States of America Abstract Environmental compounds can promote epigenetic transgenerational inheritance of adult-onset disease in subsequent generations following ancestral exposure during fetal gonadal sex determination. The current study examined the abilit