dioxin toxicity in vivo results from an increase in the dioxin-independent transcriptional activity of the aryl hydrocarbon receptor二恶英的毒性增加体内结果dioxin-independent芳基碳氢化合物受体的转录活动.pdfVIP

Dioxin Toxicity In Vivo Results from an Increase in the Dioxin-Independent Transcriptional Activity of the Aryl Hydrocarbon Receptor ´ ¤ Miguel Angel Cespedes, Maximo Ibo Galindo , Juan Pablo Couso* School of Life Sciences, University of Sussex, Brighton, East Sussex, United Kingdom Abstract The Aryl hydrocarbon receptor (Ahr) is the nuclear receptor mediating the toxicity of dioxins -widespread and persistent pollutants whose toxic effects include tumor promotion,