原创力文档docosahexaenoic acid inhibits uvb-induced activation of nf-κb and expression of cox-2 and nox-4 in hr-1 hairless mouse skin by blocking msk1 signaling二十二碳六烯酸抑制uvb-induced激活nf-κb和cox - 2的表达和nox-4 hr-1无毛小鼠皮肤通过阻断msk1信号.pdfVIP
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docosahexaenoic acid inhibits uvb-induced activation of nf-κb and expression of cox-2 and nox-4 in hr-1 hairless mouse skin by blocking msk1 signaling二十二碳六烯酸抑制uvb-induced激活nf-κb和cox - 2的表达和nox-4 hr-1无毛小鼠皮肤通过阻断msk1信号
Docosahexaenoic Acid Inhibits UVB-Induced Activation
of NF-kB and Expression of COX-2 and NOX-4 in HR-1
Hairless Mouse Skin by Blocking MSK1 Signaling
1 1 1 2 1,3,4
Md. Mostafizur Rahman , Joydeb Kumar Kundu , Jun-Wan Shin , Hye-Kyung Na , Young-Joon Surh *
1Tumor Microenvironment Research Center, College of Pharmacy, Seoul National University, Seoul, South Korea, 2 Department of Food and Nutrition, Sungsin Women’s
University, Seoul, South Korea, 3 WCU Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology,
Seoul National University, Seoul, South Korea, 4 Cancer Research Institute, Seoul National University, Seoul, South Korea
Abstract
Exposure to ultraviolet-B (UVB) radiation induces inflammation and photocarcinogenesis in mammalian skin.
Docosahexaenoic acid (DHA), a representative v-3 polyunsaturated fatty acid, has been reported to possess anti-
inflammatory and chemopreventive properties. In the present study, we investigated the molecular mechanisms underlying
the inhibitory effects of DHA on UVB-induced inflammation in mouse skin. Our study revealed that topical application of
DHA prior to UVB irradiation attenuated the expression of cyclooxygenase-2 (COX-2) and NAD(P)H:oxidase-4 (NOX-4) in
hairless mouse skin. DHA pretreatment also attenuated UVB-induced DNA binding of nuclear factor-kappaB (NF-kB) through
the inhibition of phosphorylation of IkB kinase-a/ b, phosphorylation and degradation of IkBa and nuclear translocation of
p50 and p65. In addition, UVB-induced phosphorylation of p65 at the serine 276 residue was signif
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