dynamin- and rab5-dependent endocytosis of a ca2+-activated k+ channel, kca2.3dynaminu2014u2014rab5-dependent ca2 +激活k +通道内吞作用,kca2.3.pdfVIP

Dynamin- and Rab5-Dependent Endocytosis of a Ca2+- Activated K+ Channel, KCa2.3 Yajuan Gao., Claudia A. Bertuccio., Corina M. Balut, Simon C. Watkins, Daniel C. Devor* Department of Cell Biology and Physiology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America Abstract Regulation of the number of ion channels at the plasma membrane is a critical component of the physiological response. We recently demonstrated that the Ca2+-activated K+ channel, KCa2.3 is rapidly endocytosed and enters a Rab35- and EPI64C-dependent