dynamics of the stat3 transcription factor nuclear import dependent on ran and importin-β1stat3的动态转录因子核进口依赖跑和importin-β1.pdfVIP

Dynamics of the STAT3 Transcription Factor: Nuclear Import Dependent on Ran and Importin-b1 Velasco Cimica, Hui-Chen Chen, Janaki K. Iyer, Nancy C. Reich* Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, New York, United States of America Abstract The signal transducer and activator of transcription-3 (STAT3) induces transcription of genes that control differentiation, inflammation, proliferation, and tumor cell invasion. Cytokines such as interleukin-6 and interferon stimulate the specific tyrosine phosphorylation of STAT3, w