阿莫西林干混悬剂（Amoxicillin for Suspension）.docVIP

阿莫西林干混悬剂（Amoxicillin for Suspension） 阿莫西林干混悬剂（阿莫西林干混悬剂） （阿莫西林颗粒、再林） 本品主要成份为阿莫西林，其化学名称为：（2S，5R、6R）- 3-二甲基- 6 - [（R）-（-）- 2 -氨基- 2 -（4 -羟基苯基）乙酰氨基] - 7 -氧代- 4 -硫杂- 1 -氮杂双环3.2.0 ] [庚烷- 2 -甲酸三水合物。 【性状】 类白色、淡黄色或淡橙色可流动性粉末，加水摇匀后为具有特殊气味的黄色混悬液。 【药理毒理】 本品为青霉素类抗生素，对肺炎链球菌、溶血性链球菌等链球菌属、不产青霉素酶葡萄球菌、粪肠球菌等需氧革兰阳性球菌，大肠埃希菌、奇异变形杆菌、沙门菌属、流感嗜血杆菌、淋病奈瑟菌等需氧革兰阴性菌的不产β内酰胺酶菌株及幽门螺杆菌具有良好的抗菌活性阿莫西林通过抑制细菌细胞壁合成而发挥杀菌作用，可使细菌迅速成为球状体而溶解、破裂。 【药代动力学】 口服后迅速吸收，约75%～90%可自胃肠道吸收。口服0.25g、0.5g和1g后的血药峰浓度分别为5.1mg／L、10.8mg／L和20.6mg／L，约为氨苄西林的2倍；达峰时间为2小时。食物对药物吸收的影响不显著。本品通过胎盘，脐带血中浓度为母体血药浓度的1 / 4～1 / 3。乳汁、汗液和泪液中含有微量。本品的分布容积为0.41l／kg。蛋白结合率为17%～20%。 The half-life (t1/2) ranged from 1 to 1.3 hours. After a single oral dose of 250mg and 500mg, 24% and 33% of the dosage was metabolized in the liver, respectively. About 60% of the oral dose was excreted in urine within 6 hours with a prototype drug through glomerular filtration and tubular secretion, and 20% of the oral dose was excreted in the urine from the presence of the Penicillium acid. The concentration of amoxicillin in urine is high, and the concentration of urine is 300 ~ 1300mg/L after oral administration of 250mg. Some drugs are excreted through bile, and their concentrations are higher than ampicillin. [indications] Antibiotic。 For infection by susceptible bacteria (beta lactamase producing strains): 1., hemolytic streptococcus, Streptococcus pneumoniae, Staphylococcus or Haemophilus influenzae caused by otitis media, sinusitis, pharyngitis, tonsillitis and other upper respiratory tract infections. 2. urinary tract infection caused by Escherichia coli, Proteus mirabilis or Enterococcus faecalis. 3. infection of skin and soft tissue caused by Streptococcus, Staphylococcus or Escherichia coli. 4., Streptococcus pneumoniae, Streptococcus pneumoniae, Staphylococcus or Haemophilus influenzae caused by acute bronchitis, pneumonia and other lower respiratory tract infections. 5. acute simple gonorrhea. 6. this product can be used in the treatment of typhoid fever, typhoid c