肝硬化晚期（Late cirrhosis）.docVIP

肝硬化晚期（Late cirrhosis） Late cirrhosis The causes of cirrhosis are many, mainly caused by viral hepatitis, such as hepatitis B, hepatitis C and so on. At the same time, alcoholic liver, fatty liver, cholestasis, drugs, nutrition and other factors caused by long-term damage. Viral hepatitis: at present in China, viral hepatitis, especially chronic hepatitis B, is the main cause of portal cirrhosis. Two. Alcoholism: prolonged heavy drinking is one of the factors contributing to cirrhosis. It is believed that alcohol can act as a direct toxic action on the liver. It can cause mitochondrial swelling of hepatocytes, irregular arrangement of mitochondrial cristae, and even ethanol transparent bodies, which is the manifestation of severe liver cell injury and necrosis. Three, nutritional disorders: most scholars admit that malnutrition can reduce the resistance of liver cells to toxic and infectious factors, and become the indirect cause of cirrhosis. Animal experiments have shown that animals feeding on food lacking choline or methionine can develop cirrhosis through fatty liver stages. Four, industrial poison or medicine: long-term or repeated exposure to pesticides containing arsenic, phosphorus, carbon tetrachloride, chloroform, or long-term use of certain drugs such as bisatin, isoniazid, Xin Kefen, tetracycline, methotrexate (MTX), methyldopa, can produce toxic or drug-induced hepatitis, leading to liver cirrhosis. Aflatoxin can also cause poisoning and damage to liver cells and lead to cirrhosis. Five, circulatory disorders: chronic congestive heart failure, chronic constrictive pericarditis can make the liver long-term congestion, hypoxia, causing liver cell necrosis and fibrosis, called cirrhosis of liver cirrhosis, also known as cardiogenic cirrhosis. Six, metabolic disorders such as hemochromatosis and hepatolenticular degeneration (also known as Wilson disease). Seven, cholestasis: extrahepatic bile duct obstruction or intrahepatic cholestasis bilirubin high conc