ct灌注成像在定量监测肿瘤微血管系对抗血管生成治疗的反应中的.docVIP

基于投影数据的锥形束CT功能成像方法初探 钱鹰, 周强, 韦庆杰（重庆邮电大学医学图像与信息系统研究中心，重庆 400065） 提要：目的 建立计算机仿真系统，研究基于投影数据的锥形束CT（CBCT）灌注成像的方法，探索实现在线功能图像引导的放疗（BIGRT）的可能性。方法 通过计算机仿真技术，利用大白兔动态增强CT（DCE-CT）图像数据集模拟获取CBCT动态增强扫描的投影数据集；通过对扫描对象各体素的时间密度变化进行数学建模，基于获得的投影数据集，经最优化拟合求得各体素模型的参数，获取CBCT动态增强扫描下各体素的时间密度曲线（TDC）。 结果 对比仿真系统获得的锥形束CT下各体素的时间密度曲线（TDC）和原DCE-CT获得的对应体素的TDC，发现在对比剂首次通过时的上升沿有较好吻合，在循环进入平衡后差异较大。 结论 基于投影数据可实现CBCT灌注成像，获得较为准确的血流灌注值，证明了利用集成在直线加速器上的CBCT实现在线的功能成像是可能的。 关键词：图像引导的放疗；锥形束CT；功能成像 Investigation of Functional Cone-Beam CT Imaging Method Based on Projection Data Ying QIAN, Qiang ZHOU, Qingjie WEI (Chongqing University of Posts and Telecommunications, Medical Imaging and Information system Research Center, chongqing, 400065, China) Abstract：Objective To build a computer simulation system for investigating functional cone-beam CT imaging based on projection data to realize on-line Biologic Image Guided Radiation Therapy. Methods Dynamic Contrast Enhanced CT (DCE-CT) scan are performed on rabbit. Computer simulation system is built and the cone-beam CT projection data are obtained by using the program of transferring the fan-beam data to the cone-beam data. The change of time-density of each voxel is modeled as a uniform function. Parameters of this function are resolved by using curve fitting based on the projection data. Finally, functional parameters of rabbit are computed by using existent fCT model. Results Comparing the Time-Density Curve (TDC) from cone-beam CT data in simulation system and the TDC at the same pixel from the original DCE-CT data, good fitting are found at the first increase of TDC and fault fitting are found at the other parts of TDC. Conclusion The functional cone-beam imaging can be implemented and quantified the perfusion by using projection data. Key words：IGRT, Cone-Beam CT, Functional Imaging 目前针对癌症的主要治疗手段有手术治疗、化学治疗（化疗）、放射治疗（放疗），其中放射治疗已成为癌症治疗中的最重要手段，我国约有70%以上的癌症患者根据不同的治疗目的需要接受放射治疗[1,2]。 图像引导的放射治疗技术（IGRT），通过对摆位误差，靶区运动以及剂量分布的校正，使得放疗精度得到了很大的提升[3,4]。但当前IGRT技术还是基于形态图像的