诺如病毒参考文献3.pdfVIP

Vaccine (2008) 26, 460—468 a v a i la b le at ww w.scie ncedirect. com j o u rn al h omepage: www.elsevi er.c om /locate/vaccine Intranasal administration of a recombinant adenovirus expressing the norovirus capsid protein stimulates specific humoral, mucosal, and cellular immune responses in mice a,1 a,b,∗,1 a,b a,c a Li Guo , Jianwei Wang , Hongli Zhou , Hongli Si , Min Wang , b, Bingjuan Han b, Yi Shua, Lili Ren b b a,b Jingdong Song , Jianguo Qu , Tao Hung a National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 100052, China b State Key Laboratory of Molecular Virology and Genetic Engineering, Institute of Pathogen Biology, Chinese Academy of Medical Sciences, 9# Dong Dan San Tiao, Beijing 100730, China c North-western A F University, Yangling 712100, China Received 18 May 2007; received in revised form 19 October 2007; accepted 18 November 2007 Available online 4 December 2007 KEYWORDS Summary Norovirus (NV) is a major cause of acute, epidemic nonbacterial gastroenteritis in Norovirus capsid individuals of all ages. The immunological mechanism of NV infection and the approaches used protein; to prevent infection remain to be elucidated. In this study, the specific immune responses of Adenovirus vector; BALB/c mice were assessed following intranasal immunization with a recombinant adenovirus Immune response vector expressing the genogroup II4 (GGII