复方双花颗粒对冠状动脉粥样硬化性心脏病C-反应蛋白及白细胞计数.docVIP

复方双花颗粒对冠状动脉粥样硬化性心脏病C-反应蛋白及白细胞计数 　 作者：舒士敏 路娣 张增会 韩永斌 【摘要】 　　目的 观察复方双花颗粒对冠状动脉粥样硬化性心脏病（以下简称冠心病）C-反应蛋白(CRP)及白细胞计数(WBC)的影响。方法 将143例冠心病患者随机分为2组，对照组74例予阿司匹林、β受体阻滞剂、血管紧张素转换酶抑制剂(ACEI)、硝酸酯类等冠心病治疗基础用药。治疗组69例在对照组的基础上加用复方双花颗粒，每次10 g，每日2次温开水冲服。2组均7日为1个疗程，4个疗程后观察2组用药后CRP及WBC的变化情况。结果 2组治疗后CRP、WBC均降低，与治疗前比较差异均有统计学意义（Plt;0.01）；2组治疗后CRP、WBC比较差异均有统计学意义（Plt;0.05），治疗组改善优于对照组。结论 冠心病治疗的基础用药配合清热解毒中药能更好地降低CRP、WBC水平，从而抑制冠心病慢性炎症发展，稳定粥样斑块，显著降低冠心病患者不良事件的发生率。 【关键词】 冠状动脉疾病 中药疗法 清热解毒剂 　　Therapeutic effect of Fufangshuanghua decoction on CRP and WBC of coronary atherosclerotic cardiopathy 　　【Abstract】 Objective To observe the therapeutic effect of Fufangshuanghua decoction on CRP and WBC of coronary atherosclerotic cardiopathy. Methods 143 patients with coronary disease were randomly divided into 2 groups, with 74 patients in control group and 69 in treatment group. The control group was treated by conventional treatment, including aspirin, Beta-blockers, ACEI and nitric acid ester etc. The treatment group, on the basis of control group, was treated by Fufangshuanghua decoction, 200mL dose each time, twice a day. Both groups had 4 treatment courses (28 days). The variation of CRP and WBC was recorded before and after the treatment. Results The parameters of CRP and WBC in both groups were decreased after the treatment, there was a significant difference before and after the treatment (Plt;0.01). There was a significant difference between two groups after the treatment (Plt;0.05), the therapeutic effect in treatment group was superior to control group. Conclusion In the treatment of coronary disease, with the heat-clearing and toxin-removing prescription, the conventional treatment will be more effective in lowering the CRP and WBC so as to inhibit the worsen of illness and reduce the rate of adverse reaction dramatically. 　　【Key Words】 Arteriosclerotic coronary artery; TCM therapy; Qingrejiedu decoction 　　炎症与冠状动脉粥样硬化性心脏病（以下简称冠心病）心绞痛、心肌梗死、心肌缺血再灌注损伤及经皮冠状动脉介入治疗后再狭窄形成的关系越来越受到人们的重视。冠心病的病理基础是动脉粥样硬化和