the march family e3 ubiquitin ligase k5 alters monocyte metabolism and proliferation through receptor tyrosine kinase modulation3月家族e3泛素连接酶k5改变单核细胞通过受体酪氨酸激酶调节代谢和增殖.pdfVIP

The MARCH Family E3 Ubiquitin Ligase K5 Alters Monocyte Metabolism and Proliferation through Receptor Tyrosine Kinase Modulation Roshan Karki, Sabine M. Lang, Robert E. Means* Department of Pathology, Yale University School of Medicine, New Haven, Connecticut, United States of America Abstract Kaposi’s sarcoma (KS) lesions are complex mixtures of KS-associated herpesvirus (KSHV)-infected spindle and inflammatory cells. In order to survive the host immune responses, KSHV encodes a number of immunomodulatory proteins, including the E3 ubiquitin ligase K5. In explorin