抗癌植物资源与天然产物研究（Studies on Anticancer Plant Resources and natural products）.doc

抗癌植物资源与天然产物研究（Studies on Anticancer Plant Resources and natural products） For a long time, looking for anticancer drug and natural biological resources has become a common aspiration of all countries, pharmaceutical, chemical and medical biologists. A group of scientists were extracted from natural products from plants, animal cancer and marine organisms, especially after long Chunhua new alkali, paclitaxel and derivatives of Epothilones (a wave Xiulong). That makes this work has made a breakthrough. This paper reviews the progress of research and development at home and abroad, such as the nearest search for anti-cancer plant resources and natural products, are comprehensively discussed. 1 Taxus chinensis and its natural product - taxol (commonly known as yew, Taxus) genus community gymnospermae (Gymnospemmi), Songshan Gang (Conlferopside), taxales (Taxales), Taxaceae (T. Mceae S.F.Grey (B) in the Milchlor et family of Taxus werd) under Taxus. 1.1 the anticancer mechanism of Taxol (Paclitaxel) Pharmacological experiments show that the performance of the anticancer activity of paclitaxel in two aspects: one is to rapidly dividing tumor cells, paclitaxel frozen mitotic spindle so that mitotic arrest at G phase and M phase, blocked the rapid propagation of cancer cells to death; two is to inhibit tumor cell migration so far, has been found to paclitaxel with moderate anti Pl Juan, Ln, O mice ANTI LEUKEMIA activity, Bl6 melanoma with high activity, on Lewis lung cancer and SI for C I and a lame meat transplant colorectal cancer, 1 lung cancer and breast cancer M, SRC and M in 1 breast cancer have obvious activity and have a good curative effect on ovarian cancer, also has certain curative effect on metastatic breast cancer, lung cancer, head and neck cancer, malignant melanoma, lymphosarcoma and esophageal cancer. 1.2 days of Taxus chinensis and the research and development of products of them 1.2, 1 paclitaxel research and development history, J As early as 1856 from