比马前列素滴眼液说明书（Bimatoprost eye drops.）.docVIP

比马前列素滴眼液说明书（Bimatoprost eye drops.） [name of drug] Trade name: Fitness Leader Generic name: Latanoprost Eye Drops [chemical composition] This product per 1mL containing latanoprost effective components of prostaglandin G 125, auxiliary components for water, benzoyl chloride, sodium dihydrogen phosphate and sodium hydrogen phosphate anhydrous two injection water, the chemical name is [[1R] 12 (z), beta 2 (R*), 32, 52]] -7- [3, two - 5- -2- (3- hydroxy -5- valethamate base) -5- cyclopentyl] heptanoic acid -1- methyl ethyl ester. Proper leader latanoprost eye drops [physical and chemical properties] This product is almost colorless light yellow sticky oil, its relative molecular mass is 432.58, and the chemical formula is C26H40O5. It is an inactive substance that is active until it is converted into an enzyme product in the cornea. Proper leader latanoprost eye drops [pharmacological effects] Latanoprost is a kind of novel phenyl propyl ester substituted for prostaglandin F2a, selective F2a receptor agonist. It is a substance that is inactive but rapidly penetrates into the cornea and can be hydrolyzed to active free acid in the cornea and plasma. It can increase the outflow of aqueous humor through the skin layer of the eye, but the dosage is small, but it can promote the large amount of the water supply in the room, and the liquid medicine can penetrate into the upper layer of the ciliary layer of the eyeball, which has a good effect of reducing intraocular pressure. This product can also make glaucoma patients usually plug the eyeball trabecular structure screening netcom. Proper leader latanoprost eye drops [pharmacokinetics] The product is hydrolyzed into free acid in the cornea. This free acid diffuses out of the cornea and enters the room, and the peak value of blood serum can be reached at about 2h. IOP began to decrease after 3 to 4h, The maximum decrease range was from 8 to 12h, and the intraocular pressure of 24h was not increased. The drug is excreted when