氨苄西林丙磺舒胶囊（ampicillin and probenecid capsules）.docVIP

氨苄西林丙磺舒胶囊（ampicillin and probenecid capsules） [general] Ampicillin and Probenecid Capsules Name used before English name AMPICILLIN, AND, PROBENECID, CAPSULES Pinyin name ANBIANXILIN, BINGHUANGSHU, JIAONANG [drug category] penicillins [character] this product is capsule. [pharmacological toxicology] the product of a variety of gram positive bacteria and gram negative bacteria, Gram-positive bacteria including Staphylococcus aureus, Staphylococcus epidermidis (including methicillin resistant and resistant to methicillin strains), pneumococcus, Streptococcus faecalis and streptococcus; Gram-negative bacteria including Escherichia coli and Haemophilus influenzae coli, bacteria, blue cloth, he makes Escherichia Klebsiella, proteus bacteria Po Hsuan; anaerobic bacteria including Bacillus fragilis. Ampicillin sodium is a bactericidal agent in this product, which acts on the stage of bacterial active reproduction and acts as a bactericidal agent against the inhibition of cell wall peptide biosynthesis. Probenecid for benzoic acid derivatives, it is the same with ampicillin competition tubular active transport carrier, the latter from the inhibition of renal tubular excretion, improve the blood concentration of ampicillin, prolong the blood elimination half-life (t1/2?). [] pharmacokinetics of ampicillin on gastric acid stable, oral absorption is good, after the absorption of good distribution, bile and urine drug concentration in the cerebrospinal fluid and inflammatory pleural effusion, joint effusion and bronchial secretion fluid can reach effective concentration. The blood elimination half-life (tl/2 beta) ranged from 1 to 1.5 hours. The binding rate of plasma protein was 20%. 24 hours after oral administration, the amount of urine excreted is 20% to 60% of the dosage, most of which are excreted by the prototype. Probenecid metabolism by the liver, It is mainly discharged into urine in the form of mono - amino acid compounds and acts as a metabolite to maintain its carb