超选择子宫动脉灌注化疗对宫颈癌细胞超微结构地影响论文.pdfVIP

新疆医科大学医学硕士学位论文 The effect of chemotherapy by ultraselection uterine , artery perfusion on cervical cancer cell s ultrastructural Postgraduate: Zhang Liyi Supervisor: Cheng Jingxin Abstract Objective : Through observing clinical symptom, the whole of tumor and ultrastructure kinesis changed after neoadjuvant chemotherapy (NACT), approah the mechanism of action about NACT. Methods: Four patients through clinical patho - confirmed in really cervical squamous cell carcinoma (SCC) was given NACT. All patients accord to time of intervention ago and after in the clinical and tumour part and cell ultrastructure way kinesis changed. Result: The curative effect of clinical, all of 4 case for PR, The Change of ultrastructure: cell spaces widen architectonic growth badly microvilli (MV) decrease or abolition. the cell organelle of changed : endocytoplasmic reticulum engorge for encystation, balloon pool, mitochondrion pycnosis, engorgement, cytolysosome mult, cell nucleus shape anomalism obviously, pyknosis, dissolve, disrupt, chromatospherite decrease relative, heterochromatin increase karyoplasmic ratio deflate, cellular swelling, apoptotic body appearance to frequency gradually; Inflammatory cell increase. ConclUsion: Could be revied after NACT: clinical symptom improving, gross tumor volume deflate, tumour cell ultrastructure was destroyed and process changed kinesis, tumour cell gradually apoptosis, to achieve. treated objective. Key words :neoadjuvant chemotherapy; ultr