IGF1调控区微卫星座位对金华猪生长性能的影响.pdfVIP

HEREDITAS (Beijing) 2007 2 , 29(2): 206―210 ISSN 0253-9772 研究报告 DOI: 10.1360/yc-007-0206 IGF1 1 1 2 2 赵晓枫 , 徐宁迎 , 胡晓湘 , 李宁 1. , 310029; 2. , 100094 : 类胰岛素生长因子IGF1 及其相关结合蛋白和跨膜受体IGFR 在哺乳动物的生长过程中扮演着重要角色。 本文基于最小二乘法分析了IGF1 5 ′调控序列微卫星座位对金华猪初生重, 断奶重, 120 日龄重, 180 日龄重和出 生窝重等生长性状的影响。结果表明: 286/286 基因型对金华猪初生重有显著影响(P0.05); 280/286 基因型对金 华猪开产后出生窝重影响显著(P0.05), 进一步通过等位基因平均替代效应分析发现274 bp和286 bp 等位基因 有利于提高初生重, 280 bp等位基因有利于第二胎出生窝重的提高。同时通过相关性分析发现金华猪开产母猪 出生窝重、总产仔数和产活仔数间的相关性极显著(P0.01), 因此出生窝重的增加有利于提高金华猪的产仔性 能。 : 金华猪; 微卫星; IGF1 ; 生长性状 Effects of microsatellite in the regulatory region of IGF1 on growth traits in Jinhua swine 1 1 2 2 ZHAO Xiao-Feng , XU Ning-Ying , HU Xiao-Xiang , LI Ning 1. College of Animal Science, Zhejiang University, Hangzhou 310029, China; 2. State Key Laboratory for Agrobiotechnology, China Agriculture University, Beijing 100094, China Abstract: Insulin-like growth factor 1 (IGF1) and its associated binding proteins and transmembrane receptors (IGFR) play an important role in the physiologic process of mammalian growth. The objectives of present work were to estimate the effects of microsatellite markers located in the 5′-regulatory region of the IGF1 on birth weight (BW), weaning weight (WW), weight at the 120th day, the 180th day and litter weight at birth (LWB) by the least square method in Jinhua pig. Significant effect was found for IGF1 genotype on BW (P0.05), with positive effects associated with the 286/286 geno- type, and 280/286 genotype on LWB in second parity (P0.05). Furthermore, according to analysis of allele aver