血浆同型半胱氨酸及高温作业致心血管病变关系探究.docVIP

血浆同型半胱氨酸及高温作业致心血管病变关系探究 　【关键词】 血浆 　　摘要：目的：探讨血浆同型半胱氨酸（HCY）与高温作业致心血管病变的关系。方法：接触有害作业231名，分成4组；铅作业80名，苯作业70名，锰作业42名，高温作业39名。60名健康为对照组，检测血浆HCY水平。测量血压及心电图检查。结果：高温组血浆HCY升高心血管改变与对照组有显著性差异（ｐ＜0.01）。其余3组与对照组无显著性差异。随着年龄增长、作业工人工龄延长高HCY患病率增高。结论：高HCY可能是心血管疾病的独立危险因素，血浆HCY水平升高与高温作业致心血管疾病的发展和发生存在着密切关系。 　　关键词:高温作业；心血管；血浆同型半胱氨酸 　　Study the Relationship Between the Cardiovascular Disease Caused by　the high-temperature Operation and the HCY Change 　　LIU Wei-ying, WANG De-wen 　　(The Central Hospital of Shanghai, Shanghai 200031, China) 　　Abstract: Objective： To investigate the relationship between the cardiovascular disease caused by the high-temperature operation and the HCY change. Method： 231 workers exposed to the toxic substance were chosen including 80 workers who have the contact with lead, 70 with benzene, 42 with manganese as well as 39 workers who work in the high temperature. They were divided into 4 groups separately to form comparison with the healthy group of 60 people. They were tested HCY level, blood pressure and electrocardiogram respectively. Result： The striking difference is found between the high-temperature group and the healthy one. And the difference mainly lies in the rise of HCY and the change of heart and blood vessels (plt;0.01). However, no noticeable difference was found between the healthy group and the rest three groups. As the age advances and the length of service increases, so does the risk of suffering diseases from high HCY. Conclusion: High HCY blood pressure may be an independent risk factor for the cardiovascular disease. The rise of HCY is closely related to the development and occurrence of cardiovascular disease caused by high-temperature operation. 　　Key words: High-temperature operation；Cardiovascular；Homcysteine 　　近来研究提示血浆同型半胱氨酸（Homcysteine, HCY）是检测心脑血管疾病的指标，高HCY可能是心脑血管疾病的独立危险因素之一［1］。高HCY血症与诸多心血管疾病的关系已引起关注。在职业病调查研究中，常常要研究各种有害物质与发病的关系。本文重点探讨血浆高HCY水平与常见高温作业引起心血管改变的关系。 　　1 资料与方法 　　1.1 研究对象：依据《中华人民共和国职业病防治法》，国家颁布的《职业病目录》范围内有害作业因素，选取接触有毒有害气体作业工