血清果糖胺测定在糖尿病诊断中意义.docVIP

血清果糖胺测定在糖尿病诊断中意义 　【摘要】 目的：通过检测血清果糖胺水平，评价该指标在糖尿病诊断中的临床意义。方法：采用全自动生化分析仪对62例糖尿病患者及35名正常对照组分别进行空腹血糖、果糖胺及餐后2 h血糖、果糖胺测定，比较两组间结果差异有无显著性。结果：正常对照组果糖胺值频数呈正偏态分布，参考范围：(1.86±0.23)mmol/L。糖尿病组测试结果：果糖胺异常率达91.6%，数值范围:(2.46±0.48)mmol/L，与正常对照组差异有显著意义(Plt;0.05)。对糖尿病史组，空腹血糖与餐后2 h血糖相比差异有显著性(Plt;0.05)；空腹果糖胺与餐后2 h果糖胺相比差异无显著性(Pgt;0.05)。结论：开展果糖胺试验可以反应患者测定前2周～3周内的平均血糖水平，且不受临时血糖浓度的干扰，可作为评价糖尿病近期内控制状况的一个灵敏可靠指标，因此，用于评价糖尿病短期控制程度及药物疗效具有很高的价值。 【关键词】 糖尿病；果糖胺；血糖 　　The Value of Fructosamine in the Diagnosis of Diabetes 　　Abstract:Objective To evaluate the clinical value of fructosamine in the diagnosis of diabetes by detecting its level.Methods The fasting blood glucose， postprandial blood glucose and the fructosamine of 62 patients with diabetes were detected by automatic biochemistry analyzers. The same parameters of another 35 normal persons were detected as control.Results The value of fructosamine from the control group was divided skew distribution data. The value of fructosamine was (1.86±0.23)mmol/L. As to the group of diabetes， the abnormal data of fructosamine account for 91.6% and the screened data was (2.46±0.48)mmol/L， which was significantly higher than that of the control groups(Plt;0.05). To the diabetes group， the postprandial blood glucose was significantly higher than the fasting blood glucose(Plt;0.05).But when it came to the fructosamine， the data has no significantly differences(Pgt;0.05).Conclusion The investigation of fructosamine can show the average glucose level of the diatetes patients in the recent days from one to three weeks. The occasional glucose level can’t influence its level. It can be used as a reliable and sensitive parameter and has a very important value to evaluate the curative effect of the therapy drugs and the level of glucose control in recent days. 　　Key words:Diabetes;Fructosamine;Blood glucose 　　近年来，随着临床生化检测方法学的成熟和全自动生化分析仪的广泛使用，一些与糖尿病诊断密切相关的生化指标也逐渐成为常规检查项目。血清果糖胺（Fructosamine，FRU，又叫糖化血清白蛋白）是血液中葡萄糖与白蛋白以非酶促反应产生的衍生物。可反应最近2周～3周内的平均血糖水平，是糖尿病诊断的指标之一。为此我们通过检测62例