原创力文档Effects of α—methylnorepinephrine on cardiac function and myocardium at early stage of resuscitation in rabbits.doc
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Effects of α—methylnorepinephrine on cardiac function and myocardium at early stage of resuscitation in rabbits
Effects of α—methylnorepinephrine on cardiac function and myocardium at early stage of resuscitation in rabbits
BACKGROUND： Recent studies have shown that α2-adrenergic agonists can reduce postresuscitation myocardial injury. This study was undertaken to observe changes of hemodynamics， myocardial injury markers cTnT and cardiac morphology by establishing a cardiopulmonary resuscitation model with rabbits， and to detect whether α-methyl norepinephrine （α-MNE） can reduce the myocardial injury after CPR and improve cardiac function.
METHODS： Eighteen health rabbits， weighing 2.5-3.5 kg， both male and female， were provided by the Lanzhou Institute of Veterinary Medicine. After setting up a rabbit model of cardiopulmonary resuscitation， 18 rabbits were randomly divided into three groups. The rabbits in group A as an operation-control group were subjected to anesthesia， endotracheal intubation， and surgery without induction of ventricular fibrillation. The rabbits in group B as an epinephrine group were administered with 30 μg/kg epinephrineduring CPR. The rabbits in group C as a MNE group were administered with 100 μg/kg a-MNE during CPR. The left ventricular end-diastolic pressure （LVEDP）， left ventricular pressure rise and fall rate （±dp/dt） and serum concentrations of BNP were measured. Statistical package of SPSS 10.0 was used for data analysis and significant differences between means were evaluated by ANOVA.
RESULTS： Compared to group A， the LVEDP of other two groups increased respectively （P0.05）. In group A， there were no significant differences during the observation period （P0.05）. Before inducing ventricular fibrillation， LVEDP in groups B and C increased significantly at 30 minutes after resuscitation （in group B， 290%， 2.68 ±0.44 mmHg vs. 7.76±0.68 mmHg； in group C， 262%， 2.59 ±0.53 mmHg vs. 6.80±0.54 mmHg， P0.05）. Compared to group A， cTnT was significantly higher in groups B and C （P0.05）； cTnT was increased more significantly in group B than in g
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