转化生长因子β亚型及其受体在人类系膜增生性肾小球肾炎各期病变表达的研究（Expression of transforming growth factor beta subtypes and their receptors in human mesangial proliferative glomerulonephritis）.doc

转化生长因子β亚型及其受体在人类系膜增生性肾小球肾炎各期病变表达的研究（Expression of transforming growth factor beta subtypes and their receptors in human mesangial proliferative glomerulonephritis） Expression of transforming growth factor beta subtypes and their receptors in human mesangial proliferative glomerulonephritis 2011-09-15 Wei Lin, Wang Haiyan, Zou Wanzhong, Zhang Youkang, e Jie [Abstract] Objective To study the changes of transforming growth factor beta (TGF beta) subtypes and their receptors in the pathogenesis of mesangial proliferative glomerulonephritis (MsPGN). Methods using immunoperoxidase staining techniques, detection of mild MsPGN, moderate MsPGN and severe MsPGN, TGF beta isoforms and receptors and extracellular matrix components in renal tissue (type IV collagen, fibronectin, laminin and collagen) expression. Results in mild MsPGN, there was no expression of TGF beta 1, beta 2, beta 3 and its receptor (T beta RI) in the glomeruli. During the moderate and severe MsPGN, the TGF beta subtypes and their receptors were expressed and increased in the glomeruli. At the same time, the contents of extracellular matrix in glomeruli were also significantly increased. Conclusion the subtypes of TGF beta and their receptors are involved in the over accumulation of extracellular matrix in human MsPGN. [Key words] transforming growth factor beta glomerulonephritis, membrane proliferative extracellular matrix Expression of transforming growth factor- and receptor in human mesangial B isoforms proliferative glomerulonephritis Wei Lin, Wang Haiyan, Zou Wanzhong, et al. The First Hospital, Beijing Medical University, Beijing 100034 [Abstract] Objective To observe the role of transforming growth factor (TGF) and their receptor in the B isoforms development of human mesengial proliferative glomerulonephritis (MsPGN). Methods Immuno-histochemical staining (LAB) method was used to detect the expression of TGF isoforms beta (TGF beta 1, beta 2, beta 3, type 1) receptor (T RI, and deposition of beta)