阿莫西林克拉维酸钾(注射用)（Amoxicillin, clavulanate potassium (for injection)）.docVIP

阿莫西林克拉维酸钾(注射用)（Amoxicillin, clavulanate potassium (for injection)） Amoxicillin Sodium and Clavulanate Potassium for Injection manual [name of drug] Amoxicillin Sodium and Clavulanate Potassium for Injection English Name: Amoxicillin, Sodium, and, Clavulanate, Potassium, for, Injection Chinese Pinyin: Zhusheyong, Amoxilinna, Kelaweisuanjia This product is a compound preparation, its components are amoxicillin sodium and clavulanate potassium, the ratio is 5:1. [traits] This product is white or white powder. [pharmacology and toxicology] This product is a compound preparation of amoxicillin sodium and clavulanate potassium. Amoxicillin is broad-spectrum penicillin, potassium clavulanate itself only weak antibacterial activity, but inhibitory effect of strong spectrum beta lactamase combination, can protect against amoxicillin beta lactamase hydrolysis. The antibacterial spectrum of this product is the same as amoxicillin, and it has expanded. Have a good effect on the enzyme production of Staphylococcus aureus, Staphylococcus aureus, coagulase negative Staphylococcus and Enterococcus, some of the ESBLs producing bacteria, bacteria in intestine and liver of Haemophilus influenzae, Moraxella Mora bacteria, Bacteroides fragilis has better antibacterial activity. This product has no effect on Enterobacteriaceae and Pseudomonas such as methicillin resistant Staphylococcus and enterobacter. [pharmacokinetics] Intravenous administration of this product 1.2g (amoxicillin, 1g and clavulanic acid, 0.2g), amoxicillin and clavulanic acid immediately reached the peak concentration of blood (Cmax). Pharmacokinetics were consistent with the two compartment open model. The blood elimination half-life (t1/2 beta) of amoxicillin was 1.03 + 0.11 h, and the blood elimination half-life (t1/2 beta) of clavulanic acid was 0.838 + 0.04 hr. The serum protein of two drugs had lower binding rate, about 70% of the free state of the goods found in the serum, amoxicillin and clavulanic acid were d