氯氮平说明书（Clozapine manual）.docVIP

氯氮平说明书（Clozapine manual） Clozapine Tablets manual [name of drug] Clozapine Tablets Name used before： Commercial name: English Name: Clozapine Tablets Pinyin: L danpin Pian The main ingredient of this product is clozapine, and its chemical name is 8- chloride -11- (4- methyl -1- piperazine group) -5H- Two benzo [b, e][1, 4] two, aza. Its structural formula is: C18H19ClN4 326.84 [traits] This product is light yellow. [pharmacology and toxicology] This product is two benzene and two nitrogen compounds antipsychotic drugs. 5- serotonin (5-HT2A) receptors and multiple receptors in the brain The blocking effect of DA1 receptor is stronger, and it also blocks the dopamine (DA4) receptor The blocking effect of dopamine (DA2) receptors is weak, as well as anticholinergic (M1), anti histamine (H1) and Anti adrenergic receptor action, rarely seen in extrapyramidal reactions, generally does not cause increased prolactin in the blood. It can directly inhibit the ascending activation system of brain stem reticular formation, and has a powerful sedative and hypnotic effect. [pharmacokinetics] Oral absorption is rapid and complete, food has no influence on its absorption rate and extent, and it is widely dispersed after absorption The difference in bioavailability among the tissues was large, with an average of about 50%~60%, with the liver first pass effect. The peak concentration of plasma reached 3.2 hours (1~4 h), and the half-life (t1/2) was 9 hours (3.6~14.3) Apparent volume of distribution (Vd) 4.04~13.78L/kg, high tissue binding rate. Liver metabolism, 80% In the form of metabolites occurring in urine and feces, the major metabolites are N-, demethylation, clozapine, and clozapine N-, oxide, etc.. At the same dose and weight, the serum concentrations of female patients were significant Compared with male patients, smoking can accelerate the metabolism of this product, and the rate of renal clearance and metabolism is obviously lower in the elderly. This product can be secre