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Proceedings: The Second International Conference on Building Energy and Environment 2012 Topic 1. Building energy demand and energy performance of buildings, systems, and components Building System Optimization with Respect to Mechanical and Enclosure Systems Guiyuan Han1,*, and Jelena Srebric1 1Department of Architectural Engineering, Pennsylvania State University, University Park, PA * Corresponding email: goh5067@ Keywords: Building energy, Optimization, Mechanical system, Building insulation SUMMARY Buildings are dynamic non-linear systems with a large number of components strongly affecting the total building energy consumption. It is important to optimize performance of building systems to minimize the energy consumption over the building lifespan. Specifically, this paper presents a framework to optimize building systems based on genetic algorithm due to its capabilities to introduce complex optimization problems with a minimal computational time for a large number of input parameters defining different building systems. Two case studies demonstrate the optimization framework for different enclosure and two mechanical systems. The results show that the initial investments in the enclosure insulation should take the length of building lifespan into considerations. INTRODUCTION Building energy contributes a significant fraction of the total annual energy cost. For example, in the developed countries, energy consumption of buildings represents 20%-40% of the total energy use, and this percentage is above the industry and transportation energy use in both EU and USA (Pérez-Lombard et al. 2008). The growing trend in building energy consumption will continue during the coming years due to the projected expansion of building floor area and associated energy needs.