基于酶响应的智能材料研究.pdf

白靖琨：基于酶响应的智能材料研究 基于酶响应的智能材料研究* 白靖琨 （淄博职业学院制药与生物工程系，淄博 255314 ） 摘要酶响应材料是一种新型智能材料，具有广泛的应用前景，因其优异的生物性能受到人们 的广泛关注。文中综述了近年来的酶响应水凝胶材料，总结归纳了酶响应材料的组成，酶的 作用方式，材料的响应机理；重点介绍了酶催化下材料的响应，主要包括自组装的形成、破 坏，可逆变化。与其他智能材料相比，酶响应材料生物相容性好，降解可控，是未来智能材 料的发展方向之一。 关键词凝胶酶纳米材料智能材料 中图分类号：TB381 文献标识码：A Progress in Intelligent Materials Based on Enzyme Response 1,2 1 1 BAI Jingkun , ZHANG Yu , WANG Jingxin (1. College of Chemical Engineering, China University of Petroleum (East China), Qingdao 266580; 2. Department of pharmaceutical and biological engineering, Zibo Vocational Institute, Zibo 255314) Abstract Enzyme responsive material is a new kind of intelligent material, which attract great attention since they can give excellent performance of biological properties. In this paper, the research and development of enzyme responsive materials have been introduced. The review summarizes the composition of enzyme responsive materials, the mode of enzyme action and the response mechanism of materials. The response of the materials catalyzed by enzymeis introduced emphatically, mainly including the formation, the destruction of the hydrogels and its reversible * 国家自然科学基金资助项目 ） 白靖琨：通讯作者，男，1982 年生，博士，讲师，主要从事酶响应材料及其抗菌、抗肿瘤 性能的研究 E-mail：jkbaizg@163.com 白靖琨：基于酶响应的智能材料研究 changes. Enzyme responsive hydrogels have good biocompatibility, and the degradation of the material is controllable compared with other intelligent materials. It is one of the developing direction of the future smart materials. Key words hydrogel, enzyme, nanomaterials, intelligent materials 0 引言 过去的几十年来，智能响应材料已成为材料领域的研究热点，这类材料