特质焦虑对酒精依赖患者的抑制控制的影响：同时获取ERPS和BOLD反应2008已阅读探究.pptx

Influence of trait anxiety on inhibitory control in alcohol dependent patients: Simultaneous acquisition of ERPs and BOLD responses特质焦虑对酒精依赖患者的抑制控制的影响：同时获取ERPS和BOLD反应;一、问题提出（Objectives）;3、No consensus exists about how different cognitive dimensions might be affected and whether there is a general decline in cognitive functioning or circumscribed impairments。 关于不同的维度的认知可能会受到影响，这一点并未达成一致。是否是认知功能的普通降低或者说是限制性的损伤。{有很多认知功能，他们具体情况到底怎么样还不明确，所以我要探讨} 4、Some studies, suggested that abilities which are mainly associated with right hemispheric functions are primarily affected in patients with alcohol use disorder 有些研究表明认知能力的损伤和右半球功能受到主要影响，对于酒精使用障。{表明自己为什么要用FMRI};5、The go/nogo paradigmhas been widely used to show the neural correlates of response activation and inhibition and to assess impulsivity and control processes in healthy subjects, as well as several clinical groups go/nogo范式被广泛的用于显示健康者的反应活动和抑制的神经关系，和用于评估冲动性和控制加工。也同样用于一些临床群体。{我要用的范式是有效的}。;6、In contrast to event-related potentials functional MRI of the blood oxygenation level-dependent (BOLD) response measures hemodynamic changes in the brain associated with cognitive processes with a high-spatial resolution. 相比ERP，依赖血氧水平测量和认识加工相关的大脑血氧变化的FMRI具有更高的空间分辨率。{为什么要用FMRI} 7、Epidemiological studies revealed that anxiety frequently co-occurs with alcohol use disorder。 流行病学研究表明焦虑频率和酒精使用障碍存在关系。 {表明我要研究的一个问题}。 ;二、研究假设（ Research hypothesis ）;三、Materials and methods（材料和方法 ）; Exclusion criteria were stroke, head trauma, anoxia, encephalitis, learning disability, polysubstance abuse, and comorbid neurological or psychiatric disorders including anxiety disorder disorder(except depression). 排除标准：中风，头部创伤，缺氧症，脑炎，无学习能力，多种药物乱用，伴随神经症或者精神疾???的包括焦虑障碍（抑郁除外） ; Three patients received psychotropics : two were on antidepressive medication, the other patient on anticonvulsive drugs。 In addition，one patient was on antihypertensive medication, and one received myotonolytic dru