2 塞来昔布对全膝关节置换术术后失血、疼痛与功能恢复的影响.pdfVIP

Acta Orthopaedica 2007; 78 (5): 661–667 661 Effects of celecoxib on blood loss, pain, and recovery of function after total knee replacement A randomized placebo-controlled trial 1 2 1 Andreas Meunier , Björn Lisander and Lars Good 1 2 Division of Orthopaedics and Sports Medicine, Department of Neuroscience and Locomotion, and Department of Anaesthesia, Faculty of Health Sciences, University of Linköping, Sweden Correspondence AM: andreas.meunier@lio.se 1 Submitted 06-10-05. Accepted 06-12-19 1 / 8 2 / 7 0 n o ) e v i t c A ( d Background Pain management after surgery has been Traditional non-steroid anti-inflammatory drugs t L r used as a sales argument for the use of COX-2 inhibitors, (NSAIDs) are widely used as analgesics but their e z i but their potential positive and negative effects have not use is discontinued before major surgery in order f P y been fully investigated. We thus conducted a controlled to avoid increased perioperative blood loss (Fauno b . y m l evaluation of the effect of celecoxib on perioperative et al. 1993, Slappendel et al. 2002, Weber et al. n o o c e. e blood loss, pain relief and consumption of analgesics, 2003). Traditional NSAIDs inhibit the cyclooxy- r s a u c l range of motion, and subjective outcome in conjunction genase isoenzymes COX-1 and COX-2. Selective h a t