ATF4研究.pdfVIP

Molecular Cell, Vol. 6, 1099–1108, November, 2000, Copyright 2000 by Cell Press Regulated Translation Initiation Controls Stress-Induced Gene Expression in Mammalian Cells Heather P. Harding,* Isabel Novoa,* Yuhong Zhang,* synthesis (athough the responsible kinase(s) have not Huiqing Zeng,* Ron Wek,† Matthieu Schapira,* yet been identified Brostrom and Brostrom, 1998). and David Ron*‡ Our present understanding of mammalian eIF2 ki- *Skirball Institute of Biomolecular Medicine