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7 6 Vol. 7 No. 6 2009 11 Chinese Journal of Pharmaceutics Nov. 2009 p.417 (2009 110016 HPLC(f 2) 2~16 h(r = 0.994 6) Glucotrol XL(f 2 = 69.7) 24 h f 2 R 94 A (glipizide) ( ) [1-2] HPLC 2~16 hGlucotrol XL 1 ZDY ( )BY300A ( )ZRS8G ()()PHS3C pH ( )CP225D () (99.9 %)(M 200 000M 6 000 000