生化系统稳态优化的一种二次规划算法（A two order programming algorithm for steady-state optimization of biochemical systems）.pdfVIP

生化系统稳态优化的一种二次规划算法 [摘 要] 生物技术主要是解决全球性的经济问题，可应用于医药、林牧、 轻工、化工和能源等领域，生化工程是一个多学科交叉的领域，它的 任务是把生物技术转化为生产力。正如我们所知，生化过程具有非线 性、时变性和不确定性等特点，所以，很难对它进行优化。因此，为 了提高原材料的转化率和目的产物的产率，研究人员需要提出与生化 过程特点相适应的最优化技术，从而提高生化过程的整体水平。 针对一类生化系统的稳态优化问题，在已有间接优化方法(IOM) 的目标函数中引入一个反映 S-系统解和原模型解一致性的二次项，提 出了一种改进的优化算法。该优化算法不仅得到了一致的 S-系统解与 IOM 解，而且可用现有的二次规划算法去计算。仿真结果表明了该优 化算法的实用性和有效性。 论文研究的主要内容和取得的结果如下： 1、本文选题的基本内容是，求解生化系统的稳态优化问题，把复 杂的非线性优化问题转化成 S-系统模型，S-系统模型在稳态下是线性 的，通过在目标函数中加上一个二次项，把原优化问题转化为二次规 划问题，再对其进行求解。 2、为了说明算法的有效性，将该算法应用到几个生化系统中，仿 真结果显示，本文提出的优化算法可以得到一致的 S-系统解与 IOM 解。 [关 键 词]：生化系统；稳态优化；S-系统；二次规划；优化算法 I ABSTRACT Biotechnology mainly solves the problem of global economy. It can be applied to medicine, forest, light industry, chemical industry and energy, etc. Biochemical engineering is an area that multidisciplinary crossed. Its task is to put the biological technology into productivity. As we all know, biochemical process has the characteristics of nonlinearity, time variation and uncertainty. So, it is difficult to optimize it. In order to improve the conversion rate of raw materials and the yield of the objective product, the researchers need to put forward an optimization technique which adapted with the characteristics of biochemical processes, so as to improve the overall level of biochemical processes. A new algorithm for steady-state optimization of a class of biochemical systems is proposed in this paper. A quadratic term to account for the consistency of solutions between the S-system and original model is introduced into the exist objective function of the Indirect Optimization Method (IOM). The proposed optimization algorithm not only obtains the consistent