广西南宁农村育龄地中海贫血高危孕妇产前诊断分析.pdfVIP

·156· ·专题研究 广西南宁农村育龄地中海贫血 高危孕妇产前诊断分析 尹晓林，曾丽红，周艳洁，阮丽明，周天红，张天郎，罗瑞贵，李静，张新华 【摘要】目的探索适用于在农村推广的地中海贫血(地贫)干预模式。方法依托计划生育系统，跟踪高危地贫 夫妇，176对前期筛查出的高危夫妇已经妊娠者纳入研究。结果176例孕妇中，25例孕妇失去联系，2例拒绝行产前诊 5例。其余为缺失型HbH病。26例确诊重型或中间型a或B地贫者均终止妊娠。结论依托计划生育部门主动服务， 是在农村开展地贫于预的适宜措施。 【关键词】地中海贫血；产前诊断；计划生育 714．254 【中图分类号】R 【文献标识码】A Riskof in of Prenatal for Womenwith Thalassemia DiagnosisPregmmt High VillageNanningGuangxi YlN xiao--lin，zENGLi—hong．zHOUYq，r÷ie，RUANLi—ming．zH()UTian—hong，ZHANGTian—lang．LUoRt‘i- J 303 the Liberation gui，Ljing，ZHANGXin-hua．DepartmentofHematology，NQHospitalof People0 Army。 530021。吼ina NanningGuangxi author：zHANG Corresp(mding Xin-hua，E-mail：zxh303xy@hotmail．COrIt To thethalassemiainterventionmodesuitablefor inthe [Abstract]Objectiveinvestigate applicationvillage．Meth- otis ]Sasedonthe with riskofthalassemiawerefollowed，and176 were high familyplanningsystem。couples couples studied．ResultsIn176 women，25werelosttouch，and2refusedthe theremained149 pregnant prenatal diagnosis．For were with orintermedia，4with cases，6 8thalassemia athalassemiawithathalassemiainter— diagnosed major major，15 withHbHdisease thalassemia，86witha thalassemiaminororsilent media(HbHdisease)，1 by8 or／andB accompanied 37werenorlYl8l thefetuseswithHbHdisease。5were withHbH—CS．A1lthe26 gene．and