弥漫大B细胞性淋巴瘤中t1418易位及BCL2表达的意义.pdfVIP

396 涓浗鑲跨槫涓村簥 2012骞寸39鍗风7鏈 寮ユ极澶缁嗚優鎬ф穻宸寸槫涓璽锛?4锛?8锛夋槗浣嶅強BCL2 琛ㄨ揪鐨勬剰涔? 鈶 鈶 鈶 鈶 鈶 闄嗛敠鏍 瀛ｈ強鐜 閯 缇 鏉庡皬绉 鏈遍泟澧 鎺㈣寮ユ极澶缁嗚優鎬ф穻宸寸槫锛圖LBCL锛変腑t锛?4锛?8锛夋槗浣嶅強BCL2琛ㄨ揪鐨勬剰涔夈€ 鐢ㄧ煶铚″寘鍩嬬粍缁囧厤鐤粍缁囧寲瀛 鎽樿 鐩殑锛 鏂规硶锛 娉曟娴?42渚嬫穻宸寸粨銆佽儍鑲犻亾鍜屽捊娣嬪反鐜瓑涓嶅悓鍣ㄥ畼鎴栭儴浣嶅彂鐢熺殑DLBCL涓瑿D10銆丅CL6銆丮UM1鍜孊CL2鐨勬姉鍘熻〃杈撅紝鎸夊厤鐤〃鍨 灏咲LBCL鍒嗘垚GCB-DLBCL鍜岄潪GCB-DLBCL涓や釜浜氬瀷锛涜仛鍚堥叾閾惧弽搴旓紙PCR锛夋墿澧?5渚嬫穻宸寸粨缁撳唴DLBCL鏂伴矞缁勭粐涓敱t锛?4锛?8锛 鏄撲綅鎵€褰㈡垚鐨凪BR/JH鍜宮cr/JH閲嶇粍鍩哄洜銆 142渚婦LBCL涓紝75渚嬶紙52.8%锛夎〃杈綛CL2銆傚垎鍨嬩负GCB-DLBCL鐨?1渚嬩腑锛?8渚 缁撴灉锛 锛?5.3%锛夎〃杈綛CL2锛涘垎鍨嬩负闈濭CB-DLBCL鐨?1渚嬩腑锛?7渚嬶紙62.6%锛夎〃杈綛CL2锛屼袱鑰呴槼鎬х巼姣旇緝鏈夋樉钁楁€у樊寮傦紙P=0.002锛夈€傚悓鏃讹紝BCL2 鐨勮〃杈鹃槼鎬х巼鎸変笉鍚屽櫒瀹樻垨閮ㄤ綅鍙戠敓鐨凞LBCL浣滄瘮杈冿紝缁撴灉涔熷瓨鍦ㄦ樉钁楁€у樊寮傦紙P=0.01锛夈€?8.7%鐨勬穻宸寸粨缁撳唴DLBCL涓湁t锛?4锛 18锛夋槗浣嶏紝闃虫€х梾渚嬩富瑕佽浜嶨CB-DLBCL涔嬩腑銆 t锛?4锛?8锛夋槗浣嶆槸GCB-DLBCL浜氬瀷鐨勯仐浼犲鐗瑰緛锛孊CL2琛ㄨ揪鍦ㄤ笉鍚屼簹鍨嬪拰涓 缁撹锛 鍚屽櫒瀹樻垨閮ㄤ綅鍙戠敓鐨凞LBCL涓湁鏄捐憲鎬у樊寮傘€ 鍏抽敭璇 寮ユ极澶缁嗚優鎬ф穻宸寸槫 t锛?4锛?8锛 BCL2 doi:10.3969/j.issn.1000-8179.2012.07.009 Significance of t(14;18) Translocation and BCL2 Expression in Diffuse Large B-cell Lymphoma 1 1 1 2 2 Jinbiao LU , Juling JI , Qun E , Xiaoqiu LI , Xiongzeng ZHU Correspondence to: Jinbiao LU, E-mail: jblu1116@ 1Department of Pathology, Nantong University Medical School, Nantong 226001, China 2Department of Pathology, Fudan University Cancer Hospital, Shanghai 200032, China This work was supported by the Scientific Funds of Nantong City (No. K2008013) Abstract Objective: This study aims to explore the significance of t ( 14; 18 ) translocation and BCL2 expression in diffuse large B-cell lymphoma ( DLBCL ). Methods: Data from 142