复方金芩颗粒制备工艺及质量标准的研究.pdf

1.4 试剂与试药 2 制备工艺研究 2.1 处方 2.2 药材的鉴定及前处理 2.3 提取工艺 2.4 工艺流程图 2.5 提取工艺考察 2.5.1 挥 2.5.2 醇提工艺考察 2.6 制剂成型工艺研究 2.6.1 加辅料量的考察 2.6.2 甜 2.6.3 润湿剂的选择 2.6.4 颗粒剂流动性和吸湿性考察 3 质量标准 3.1 检查 3.2 鉴别 3.3 含量测定 3.3.1 色谱条件 : 定了复方金芩颗粒醇提取工艺，即提取时间为每次 1.0 小时，提取次数为 2 度为 50%，乙醇用量为 8 倍量。以干浸膏粉与糊精 1:2 配比，以 2.5 以 80 中绿原酸的含量限度，每克含绿原酸(C H O )不得少于 2.5mg 。 16 18 9 结论： 的质量标准。 关键词：复方金芩颗粒 制备工艺 质量标准 含量测定 1 foliumisatidis, radix scutellariae, and rhiz identification for the preparation;Using HPLC chlorogenic acid in honeysuckle as a determin Pharmacopoeia,the study on quality standard of Fufangjinqin granules Results: Using orthogonal test method, preferred the volatile oil β process.The proportion of volatile oil and β-cyclodextrin was 1:8,the was 45 ℃,and the inclusion time was 3h. the chlorogenic acid.The prescription was boiled with 50% ethanol 50% ethanol of its own weight was added, each decoction last was gathered, then filtered. Two times the dextrin of dry ex added, 80% ethanol and 2.5% steviosin were added and mixed, granulated formability and good fluidity. content limits, the amount of chlorogenic acid (C16H18O9 measured to be not less than 2.5mg per gram. Conclusion: The preparation process of Fufang convenient that can be used for industrial production.Materials TLC, the samples had the same colors in the same the negative samples has no interference.This 2