TLR激动和剂imiquimod的研究进展.pptVIP

Imiquimod--a TLR7 agonist Xiaochen Yu 2013 10 21 Introduction Imiquimod was the first small molecule approved for topical use in humans that was shown to act through the Toll-like receptor (TLR) pathway. Imiquimod activates innate immune cells that express TLR7 including plasmacytoid dendritic cells (pDC), B cells and likely some monocytes. Depending on the cell type, this activation results in secretion of cytokines including interferon-α (IFN-α) and others, upregulation of costimulatory molecule expression and maturation and/or proliferation. It was first identified as a