中药多糖的分子修饰及其药理活性研究进展.PDF

·1074 · 中草药 Chinese Traditional and Herbal Drugs 第 46 卷 第 7 期 2015 年 4 月 中药多糖的分子修饰及其药理活性研究进展 * * 郭浩杰，杨严格，安 乐，何明睿，黄锦维，李鑫姝，卿素珠 ，张为民 西北农林科技大学动物医学院，陕西 杨凌 712100 摘 要：中药多糖的分子修饰是运用物理、化学、生物等方法对其主链或侧链的某些特殊结构或功能基团进行修饰，使多糖 的某些物理化学性质和空间结构发生改变，以增强其生物活性。其中物理方法包括超声波方法和辐照技术；化学方法主要有 硫酸化、磷酸化、乙酰化、羧甲基化、烷基化、磺酰化和硒化等方法；生物方法也称酶法，分为酶降解法和酶合成法。经过 分子修饰后中药多糖的物化性质和空间结构发生一定改变，使得多糖的免疫调节、抗病毒、抗肿瘤、抗氧化等药理活性明显 增强。就近年来中药多糖的主要分子修饰方法及分子修饰后多糖的药理活性研究进展进行综述。 关键词：中药；多糖；分子修饰；免疫药理学；酶法 中图分类号：R284 ；R285 文献标志码：A 文章编号：0253 - 2670(2015)07 - 1074 - 07 DOI: 10.7501/j.issn.0253-2670.2015.07.024 Research progress in molecular modification and pharmacological activity of Chinese materia medica polysaccharides GUO Hao-jie, YANG Yan-ge, AN Le, HE Ming-rui, HUANG Jin-wei, LI Xin-shu, QING Su-zhu, ZHANG Wei-min College of Veterinary Medicine, Northwest A F University, Yangling 712100, China Abstract: Molecular modification of Chinese materia medica polysaccharides (CMMP) is considered as the technology of modification on some special structure or functional group in the main chain or the side chain of polysaccharides on the purpose of changing certain physicochemical properties and the spatial structure of polysaccharides by using physical, chemical and biological methods which can enhance the biological activity. Physical methods mainly include ultrasonic method and irradiation technology. Chemical methods refer to sulfation, phosphorylation, acetylation, carboxymethylation, alkylation, sulfonylation, selenylation, and so on. Biological method is also called the enzymatic modification containing enzyme degradation and enzymatic synthesis. In recent years, it has been shown that the physicochemical properties and spatial structure of CMMP could be changed after modification, which could make their immunopharmacology activity, such as immune a