吴茱萸碱分散片及吴茱萸碱不同处理方法的溶出度-中国实验方剂学杂志.docVIP

吴茱萸碱分散片及吴茱萸碱不同处理方法的溶出度测定 盛蓉，陈佳2，，（1.成都中医药大学附属医院，四川 成都610072；2. 成都中医药大学，四川 成都610075） [摘要] 目的：。方法：·min-1，以HPLC法作为定量方法测定溶出度；制备吴茱萸碱-泊洛沙姆188固体分散体、吴茱萸碱超微粉及吴茱萸碱超微粉-泊洛沙姆188固体分散体，并用HPLC法测定溶出度。结果：45 min溶出度达到60%以上。 结论：[关键词] 吴茱萸碱分散片；；issolution rate test of Evodiamine dispersible tablets and the Evodiamine been processed by different methods SHENG Rong1, CHEN Jia2,SONG Ying1,ZHAO Xue-li2 （1. The Affiliated Hospital of Chengdu University of Trditional Chinese Medicine, Chengdu 610072, China; 2 Pharmacy College, Chengdu University of Trditional Chinese Medicine, Chengdu 610075, China ) ABSTRACT: OBJECTIVE To Determine the dissolution rate of evodiamine dispersible tablets and the evodiamine been processed by different methods. METHODS According to the second dissolution method in Chinese Pharmacopoeia 2010 edition,1%SDS solution of 900 mL was used as the dissolution medium and the rotation speed was 100 r·min-1,HPLC method was as the quantitative method to determine the dissolution rate;to prepare the Evodiamine-poloxamer 188 solid dispersions,evodiamine ultrafine powder and evodiamine ultrafine powder-poloxamer 188 solid dispersions,dissolution rate were determined by HPLC. RESULTS The dissolution rate of Evodiamine dispersible tablet was more than 60% at 45 min. The dissolution rate of evodiamine ultrafine-poloxamer 188 solid dispersions was more higher than others. CONCLUSION In our study the established dissolution rate method of evodiamine dispersible tablets is simple and rapid,which can be as the dissolution rate test method of Evodiamine dispersible tablets; evodiamine is almost insoluble in water,ultrafine grinding combined with solid dispersion technology can significantly improve the dissolution rate of evodiamine . KEYNWORDS: evodiamine dispersible tablets;evodiamine;different processing methods;dissolution rate 吴茱萸碱(Evodiamine)是临床常用中药吴茱萸(Evodia rutaecarpa)的的主要活性生物碱[1]，本课题组前期对我院治疗痛风性关节炎疗效较好的中药复方进行拆方、大类成分、单一成分的逐步筛选，首次发现吴茱萸碱具有降血尿酸和抑制模型大鼠关节足肿胀作用[]，根据前期药效学研究及临床用药需求，